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Drug intelligence / Profile preview
[11C]raclopride + [18F]fallypride
- Development stage
- Unknown
- Lead developer
- ABX
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[11C]raclopride and [18F]fallypride are radioligands used in positron emission tomography (PET) for imaging dopamine D2/D3 receptors in the brain. [11C]raclopride is a competitive D2/D3 antagonist (KD ~1-10 nM) that is sensitive to changes in endogenous dopamine levels and is primarily used for imaging striatal dopamine receptors. [18F]fallypride is a high-affinity ligand suitable for imaging extrastriatal dopamine D2/D3 receptors. The longer half-life of 18F (110 min) compared to 11C (20 min) makes [18F]fallypride more practical for certain studies, particularly pharmacologic challenge studies. Both radioligands are widely used in neuroscience research to study dopamine receptor availability and changes in endogenous dopamine concentration.
- Other names
- [11C]RAC[18F]FP
02
Targets
DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)
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