Drug intelligence / Profile preview

[11C]raclopride + [18F]fallypride

Development stage: Unknown
Lead developer: ABX
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

[11C]raclopride and [18F]fallypride are radioligands used in positron emission tomography (PET) for imaging dopamine D2/D3 receptors in the brain. [11C]raclopride is a competitive D2/D3 antagonist (KD ~1-10 nM) that is sensitive to changes in endogenous dopamine levels and is primarily used for imaging striatal dopamine receptors. [18F]fallypride is a high-affinity ligand suitable for imaging extrastriatal dopamine D2/D3 receptors. The longer half-life of 18F (110 min) compared to 11C (20 min) makes [18F]fallypride more practical for certain studies, particularly pharmacologic challenge studies. Both radioligands are widely used in neuroscience research to study dopamine receptor availability and changes in endogenous dopamine concentration.

Other names: [11C]RAC[18F]FP

Targets

DRD3 (Dopamine receptor D3)DRD2 (Dopamine D2 Receptor)

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